Transposagen | Rat Model ID: AbatTn(sb-T2/Bart3)2.163Mcwi

Abat^{Tn(sb-T2/Bart3)2.163Mcwi}

Insertion Overview

UCSC Blat Alignment
Insertion Location:	intron 1
5' Flanking Sequence:	TACATGAGGTTTGGACATGCACAGCCTTTTAATGTCATGGGGGCCCTGGA AGAAATCCCCACAGATAGTAAGAGCTTAGTACCTATATTCctag

Gene
***Rat Entrez Gene If Available; Else Human or Mouse

Symbol:	Abat
Name:	4-aminobutyrate aminotransferase
Synonyms:	Gabat\|MGC93392\|beta-AlaAT
Chromosome:	N/A

Associated Diseases

Disease	Disease Class	Sub Category
Congenital Hypotonia	CNS & Neurological Disorder	Muscle & movement disorders
EEG abnormalities; Acquired Aphasia with Epilepsy	CNS & Neurological Disorder	Episodic Disorders
Hyperreflexia; Motor Neuron Disease	CNS & Neurological Disorder	Neurodegenerative-Muscle & movement disorders
Hypotonia	CNS & Neurological Disorder	Muscle & movement disorders
Hypotonia of the Eye	CNS & Neurological Disorder	Disease of the eye
Infantile Hypotonia	CNS & Neurological Disorder	Pregnancy, perinatal, infantile
Neurotransmitter Metabolism Error	CNS & Neurological Disorder
Psychomotor Retardation (depression)	CNS & Neurological Disorder	Mental Behavioral Disorders
Refractory Seizures	CNS & Neurological Disorder	Episodic Disorders
Transaminase Deficiency	Metabolic Disorders

Gene Ontology Function Process Component

GO	Term	Evidence	Pubmed
GO:0003867	4-aminobutyrate transaminase activity	IDA	10447691
GO:0003867	4-aminobutyrate transaminase activity	ISS
GO:0003867	4-aminobutyrate transaminase activity	ISS
GO:0016740	transferase activity	IEA
GO:0030170	pyridoxal phosphate binding	ISS
GO:0032145	succinate-semialdehyde dehydrogenase binding	ISS
GO:0042803	protein homodimerization activity	ISS
GO:0047298	(S)-3-amino-2-methylpropionate transaminase activity	IEA

Homologene Orthology (Human/Mouse)

Taxon	Symbol	Synonyms	Chromosome
human	ABAT	FLJ17813\|GABA-AT\|GABAT\|NPD009	N/A
mouse	Abat	9630038C02Rik\|AI255750\|ENSMUSG00000051226\|Gabaat\|Gabat\|Gm9851\|I54\|Laibat\|X61497	N/A

Related Links

Rat Model Source

Medical College of Wisconsin