Producers of MutaRat™ Knockout Animal Models

Transposagen is dedicated to providing unique animal models of human diseases for drug discovery and development. The company’s MutaRat™ Knockout Animal Models will enable a greater scrutiny of candidate drugs and will facilitate more favorable testing in humans saving millions in development dollars and creating new drug targets for the treatment of disease.

About 89% of all compounds tested for drug use fail during the final stages of approval due to unacceptable side effects or a lack of efficacy, typically after investments of more than US $400 million. There is a clear need to screen drugs in animal models that better reflect human physiology and toxicology before entering the most expensive phases of drug testing in humans. Transposagen has the only technology that can efficiently create novel mutations in the rat, and rapidly determine the location of the mutation. While mice have proven to be a useful rodent model and techniques have been developed for routine disruption of their genes, in many circumstances rats are a superior laboratory animal for studying and modeling human disease.